Bupropion in the uk, and a new treatment for depression, that would be wonderful, because we had heard about it for a long time, and all of sudden we are getting it in a pill.
Paul: So you have these two drugs that you are told effective. And then you get a third one where it is like they have taken the two and mixed them together. they are mixing it in such a way that it makes them completely ineffective. Is that the case right now? Do you think that's the case?
Dr. Valenstein: It's the case now?
Paul: Yep.
Dr. Valenstein: Yeah. I mean, we are still trying to figure out what happened. We just want to hear from the patients, and I know it's difficult to get them on a new drug. I guess part of that is because the stigma, and there is a lot of stigma. So I've been doing these patient surveys, and it's interesting to hear how people feel about this, they that. There was a whole other drug that we had been talking about that was approved, called levocetirizine, which is a different drug, and it was approved about a year ago, and there was a lot of concern about this drug being too potent to be effective, and also you know the FDA had never approved a drug where the was so toxic. And I think that the FDA is now reviewing that.
Paul: So there is something called a 'toxic phase.'
Dr. Valenstein: There is. Yeah, is a toxic phase, and you know we are looking at a much smaller dose. We are looking at a taper schedule that will give a lot of patients, if they can tolerate the therapy and if they are still able to tolerate the drug that dose should be reduced. So we are trying to get those patients off the taper schedule or first three levels of the drug, just before they start using it. If people can tolerate that, then I would think we could get them on the taper schedule. But you know, we don't have the information yet.
Paul: I'm not trying to be a stick in the mud about this, but I think you all need to talk about this, you need to explain the patients what's going on, but you need to explain it in a way that they take it seriously.
Dr. Valenstein: Absolutely. I mean the patients are so afraid, and when I was a doctor and telling them that, oh, this drug is so powerful, and the other drug that was approved just as powerful, and it's an anti-depressant, it is so safe, and all of these other drugs are not safe, and people die, die from all of these other drugs.
Paul: So how do you feel about, know, people who say, like, oh, these are just more antidepressants. Like, you know, we didn't really need more antidepressants, we just have to be more careful not use them to the point where they actually cause harm, or we have to use them more often. Are those drugstore matte bronzer uk things that you believe? And are saying this is really an abuse of the drugs?
Dr. Valenstein: Well, I mean, think that's a very interesting question. I mean, that's exactly my question to them, and that's where I think the controversy exists. There is no question that are going to be people who misuse the drugs, or them without drugs being used correctly. It's a really hard thing to regulate because you really can't, know, don't know what is going on, and you can't prove the drug has done anything to you physically. This is a drug that really one of the most powerful drugs available on the market, and then you also have people who to such high levels of the drug, and it's so easy to abuse, and it's so easy to get them on it, that we don't know how to treat it.
Paul: I'm glad you went there. So are hearing from patients that they are starting with this, and then they are getting off the drug?
Dr. Valenstein: Yeah. And so we have to do a lot of work. I mean, we are talking about an antidepressant, you know, one of the most powerful drugs available on the market. So we have to keep people on it for as long we can. It's the only drug that works for people who are depressed. So, we going to give it them. They are also going to have other antidepressants, and we're going to tell them keep trying those other drugs, too.
Paul: Yeah. So you keep putting them on this drug, and they really need to be on the other pharmaceutical?
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